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Heart rate variability and salivary cortisol in very preterm children during school age
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4107696
Author(s) Urfer-Maurer, Natalie; Ludyga, Sebastian; Stalder, Tobias; Brand, Serge; Holsboer-Trachsler, Edith; Gerber, Markus; Grob, Alexander; Weber, Peter; Lemola, Sakari
Author(s) at UniBasel Urfer, Natalie
Grob, Alexander
Gerber, Markus
Ludyga, Sebastian
Brand, Serge
Year 2018
Title Heart rate variability and salivary cortisol in very preterm children during school age
Journal Psychoneuroendocrinology
Volume 87
Pages / Article-Number 27-34
Mesh terms Autonomic Nervous System, physiopathology; Child; Female; Gestational Age; Heart Rate, physiology; Humans; Hydrocortisone, physiology; Hypothalamo-Hypophyseal System, physiopathology; Infant, Extremely Premature, physiology; Infant, Premature, growth & development; Male; Pituitary-Adrenal System, physiopathology; Polysomnography, methods; Saliva; Sleep, physiology; Sleep Stages, physiology
Abstract The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study. Polysomnography (PSG) assessments were obtained during a night at the children's home in lying position at rest (wake) and during different sleep stages (stage 2 sleep, slow wave sleep, rapid-eye-movement sleep). Autonomic function was assessed by use of heart rate variability, specifically low frequency power (LF), high frequency power (HF), total spectral power (Tot Pow), and the LF/HF ratio. HPA axis activity was measured using salivary cortisol the next morning at awakening, 10, 20, and 30min later. Children born very preterm had lower LF/HF ratio during wake and stage 2 sleep compared to full-term children. Moreover, higher LF, Tot Pow, and LF/HF ratio during wake, stage 2 sleep, and REM sleep were related to more post-awakening cortisol secretion. The present study provides evidence on long-term ANS alterations after very preterm birth. Moreover, findings suggest a relation between the ANS and the HPA axis and therefore support the notion of mutual feedback between the two human stress systems.
Publisher Elsevier
ISSN/ISBN 0306-4530 ; 1873-3360
edoc-URL https://edoc.unibas.ch/64578/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.psyneuen.2017.10.004
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/29035709
ISI-Number WOS:000418968300004
Document type (ISI) Journal Article
 
   

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