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Evolution of Arabidopsis MIR genes generates novel microRNA classes
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 40883
Author(s) Vazquez, Franck; Blevins, Todd; Ailhas, Jérôme; Boller, Thomas; Meins, Frederick
Author(s) at UniBasel Boller, Thomas
Meins Jr., Frederick
Vazquez, Franck
Year 2008
Title Evolution of Arabidopsis MIR genes generates novel microRNA classes
Journal Nucleic Acids Research
Volume 36
Number 20
Pages / Article-Number 6429-38
Abstract In Arabidopsis, canonical 21-nt miRNAs are generated by Dicer-like (DCL) 1 from hairpin precursors. We have identified a novel class of functional 23- to 25-nt long-miRNAs that is generated independently from the same miRNA precursors by DCL3. Long-miRNAs are developmentally regulated and in some cases have been conserved during evolution implying that they have biological functions. Plant microRNA genes (MIR) have been proposed to evolve by inverted duplication of the target gene. We found that recently evolved MIR genes consistently give rise to long-miRNAs, while ancient MIR genes give rise predominantly to canonical miRNAs. Transcripts from inverted repeats representing evolving proto-MIR genes were processed by DCL3 into long-miRNAs and also by DCL1, DCL2 or DCL4 depending on hairpin stem length to produce different sizes of miRNAs. Our results suggest that evolution of MIR genes is associated with gradual, overlapping changes in DCL usage resulting in specific size classes of miRNAs.
Publisher Oxford University Press
ISSN/ISBN 0305-1048 ; 1362-4962
Full Text on edoc Available
Digital Object Identifier DOI 10.1093/nar/gkn670
PubMed ID
ISI-Number WOS:000260977500017
Document type (ISI) Journal Article

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