Parkinson's Disease (PD) is a prominent and severe neurodegenerative disease that affects about 2% of our population, particularly the elderly. It is considered to be one of the protein aggregation diseases, which also include Alzheimer’s disease and Huntington's disease.
In this 4-year Sinergia project, we will study PD from a structural perspective in situ, using human brain tissue and fluids from PD patients. We will translate this information to the cellular level and to animal models for detailed structural, dynamic and cell biological analysis, and compare these findings with those obtained from human samples.
The unique combination of methods employed here, and their application to human PD brain tissue, and cell and animal models for PD will allow screens to be made for novel proteins that may be so far unrecognized players in the development of PD. This research will provide a better mechanistic insight into the molecular processes underlying the progression of neurodegeneration in Parkinson's disease, and may identify novel PET tracers or even drug targets to help understand and treat this debilitating disease.