The PLK4-STIL-SAS-6 module at the core of centriole duplication

Research Database / FORSCHUNGSDATENBANK

Publication 3978972 | Verified

Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

The PLK4-STIL-SAS-6 module at the core of centriole duplication

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3978972
Author(s)	Arquint, Christian; Nigg, Erich A.
Author(s) at UniBasel	Nigg, Erich Arquint, Christian
Year	2016
Title	The PLK4-STIL-SAS-6 module at the core of centriole duplication
Journal	Biochemical Society Transactions
Volume	44
Number	5
Pages / Article-Number	1253-1263
Abstract	Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis.
Publisher	Portland Press
ISSN/ISBN	0300-5127 ; 1470-8752
edoc-URL	http://edoc.unibas.ch/57020/
Full Text on edoc	No
Digital Object Identifier DOI	10.1042/BST20160116
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/27911707
ISI-Number	WOS:000392729900007
Document type (ISI)	Article

06/05/2024

Research Database / FORSCHUNGSDATENBANK