Departement Public Health / Nursing Science (Katapodi)
Hintergrund: More than 200‘000 women in the United States are diagnosed with breast cancer every year. Most of these women undergo breast cancer surgery. Depending on the stage of the disease at the time of diagnosis and the menopausal status of the woman, post-surgical treatment(s) may include radiation therapy (RT), chemotherapy (CTX), and/or hormonal therapy. However, findings from a series of retrospective studies suggest that breast symptoms (i.e., symptoms that occur in the breast scar area and/or in the ipsilateral arm) following breast cancer surgery occur in 13% to 72% of women and have a significant impact on women’s mood, sleep pattern, and functional status, including limited mobility of the ipsilateral arm and shoulder.
Zielsetzung: The specific aims of the study are to (1) determine the prevalence, severity, and the timing of the occurrence of breast symptoms (i.e., neuropathic pain, paresthesias, strange sensations, swelling, and weakness) in the breast and ipsilateral arm; (2) determine the prevalence and the timing of the occurrence of sensory changes, changes in shoulder mobility, changes in grip strength, edema, and the level of interference with function in the breast and ipsilateral arm; (3) compare differences in anxiety, depressed mood, fatigue, sleep disturbance, functional status, and quality of life (QOL) in women who do and do not experience neuropathic pain; and (4) determine factors that predict the development of neuropathic pain.
Design / Methode: This descriptive, longitudinal study consisted of a sample of 398 women who undergo breast cancer surgery, Women’s level of anxiety, depressed mood, functional status, fatigue, sleep disturbance, and QOL were evaluated at baseline (3-4 days pre-surgery) and longitudinally (i.e., up to 60 months). Finally, the study will attempt to determine the genetic factors that contribute to the development of these symptoms following breast cancer surgery.
Erwarteter Nutzen / Relevanz (z.B. für Public Health): The number of cancer survivors in the U.S. will reach 18 million by 2022. Breast cancer survivors constitute a large majority of this population. The study contributes to the development of interventions designed to enhance self-management of breast cancer survivors.