B-CaSS Breast Cancer Symptom Study
Project funded by own resources
Project title B-CaSS Breast Cancer Symptom Study
Principal Investigator(s) Katapodi, Maria
Miaskowski, Christine
Co-Investigator(s) Conley, Yvette
Project Members Ming, Chang
Kohler, Carmen
Organisation / Research unit Departement Public Health / Pflegewissenschaft (Katapodi)
Project start 01.01.2017
Probable end 31.12.2020
Status Active

Hintergrund: More than 200‘000 women in the United States are diagnosed with breast cancer every year. Most of these women undergo breast cancer surgery. Depending on the stage of the disease at the time of diagnosis and the menopausal status of the woman, post-surgical treatment(s) may include radiation therapy (RT), chemotherapy (CTX), and/or hormonal therapy. However, findings from a series of retrospective studies suggest that breast symptoms (i.e., symptoms that occur in the breast scar area and/or in the ipsilateral arm) following breast cancer surgery occur in 13% to 72% of women and have a significant impact on women’s mood, sleep pattern, and functional status, including limited mobility of the ipsilateral arm and shoulder.

Zielsetzung: The specific aims of the study are to (1) determine the prevalence, severity, and the timing of the occurrence of breast symptoms (i.e., neuropathic pain, paresthesias, strange sensations, swelling, and weakness) in the breast and ipsilateral arm; (2) determine the prevalence and the timing of the occurrence of sensory changes, changes in shoulder mobility, changes in grip strength, edema, and the level of interference with function in the breast and ipsilateral arm; (3) compare differences in anxiety, depressed mood, fatigue, sleep disturbance, functional status, and quality of life (QOL) in women who do and do not experience neuropathic pain; and (4) determine factors that predict the development of neuropathic pain.

Design / Methode: This descriptive, longitudinal study  consisted of a sample of 398 women who undergo breast cancer surgery, Women’s level of anxiety, depressed mood, functional status, fatigue, sleep disturbance, and QOL were evaluated at baseline (3-4 days pre-surgery) and longitudinally (i.e., up to 60 months). Finally, the study will attempt to determine the genetic factors that contribute to the development of these symptoms following breast cancer surgery.

Erwarteter Nutzen / Relevanz (z.B. für Public Health): The number of cancer survivors in the U.S. will reach 18 million by 2022. Breast cancer survivors constitute a large majority of this population. The study contributes to the development of interventions designed to enhance self-management of breast cancer survivors.

Keywords treatment related symptoms
Financed by Other funds

Cooperations ()

  ID Kreditinhaber Kooperationspartner Institution Laufzeit - von Laufzeit - bis
3977917  Katapodi, Maria  Miaskowski, Christine, Professor  University of California San Francisco School of Nursing  01.01.2017  31.12.2020 
3978038  Katapodi, Maria  Conley, Yvette Prof.  University of Pittsburgh School of Nursing  01.01.2017  31.12.2021 

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