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The hypothalamic-pituitary-adrenal axis in critical illness
JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)
 
ID 3975287
Author(s) Schuetz, P.; Muller, B.
Author(s) at UniBasel Müller, Beat
Year 2006
Title The hypothalamic-pituitary-adrenal axis in critical illness
Journal Endocrinology and Metabolism Clinics of North America
Volume 35
Number 4
Pages 823-838
Keywords Adrenocorticotropic Hormone/physiology; *Critical Illness/therapy; Humans; Hydrocortisone/physiology; Hypothalamo-Hypophyseal System/*physiopathology; Intensive Care/methods; Pituitary-Adrenal System/*physiopathology
Abstract The hypothalamic-pituitary-adrenal response to stress is a dynamic process. The homeostatic corrections that have emerged in the course of human evolution to cope with the catastrophic events during critical illness involve a complex multisystem endeavor. Although the repertoire of endocrine changes has been probed in some detail, discerning the vulnerabilities and failures of this system is far more challenging. One of the most controversially debated topics in the current literature is the characterization and optimal treatment of allegedly inadequate adaptations of the hypothalamic-pituitary-adrenal axis during critical illness. This outline attempts to touch briefly some of the debated issues, stir the discussion, and thereby contribute to resolving the dispute.
Publisher Saunders
ISSN/ISBN 0889-8529 ; 1558-4410
edoc-URL http://edoc.unibas.ch/56705/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ecl.2006.09.013
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/17127149
Document type (ISI) Review
 
   

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