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Volumetric capnography in infants with bronchopulmonary dysplasia
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3925780
Author(s) Fouzas, Sotirios; Häcki, Christoph; Latzin, Philipp; Proietti, Elena; Schulzke, Sven; Frey, Urs; Delgado-Eckert, Edgar
Author(s) at UniBasel Delgado-Eckert, Edgar
Year 2014
Title Volumetric capnography in infants with bronchopulmonary dysplasia
Journal Journal of Pediatrics
Volume 164
Number 2
Pages / Article-Number 283-8.e1-3
Mesh terms Bronchopulmonary Dysplasia, physiopathology; Capnography, methods; Cross-Sectional Studies; Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases, physiopathology; Lung, physiopathology; Male; Reproducibility of Results; Respiratory Rate; Retrospective Studies; Severity of Illness Index; Tidal Volume
Abstract To assess the feasibility of using volumetric capnography in spontaneously breathing small infants and its ability to discriminate between infants with and without bronchopulmonary dysplasia (BPD).; Lung function variables for 231 infants (102 term, 52 healthy preterm, 77 BPD), matched for post-conceptional age of 44 weeks, were collected. BPD was defined as supplemental oxygen requirement at 36 weeks post-menstrual age. Tidal breath-by-breath volume capnograms were obtained by mainstream capnography. The capnographic slope of phase II (SII) and slope of phase III (SIII) were calculated and compared between study groups. The effect of BPD, tidal volume (VT), respiratory rate (RR), and prematurity on the magnitude of the slopes was assessed.; SII was steeper in infants with BPD (100 ± 28/L) compared with healthy preterm (88 ± 22/L; P = .007) and term infants (79 ± 18/L; P < .001), but this finding was attributed to differences in VT, RR, and gestational age. SIII was steeper in the BPD group (26.8 ± 14.1/L) compared with healthy preterm (16.2 ± 6.2/L; P < .001) and term controls (14.8 ± 5.4/L; P < .001). BPD was a significant predictor of SIII independently of VT, RR, and gestational age. The ability of SIII to discriminate between BPD and controls was significantly higher compared with lung clearance index (area under the curve 0.83 vs 0.56; P < .001).; Volumetric capnography may provide valuable information regarding functional lung alterations related to BPD and might be considered as an alternative to more involved lung function techniques for monitoring chronic lung disease during early infancy.
Publisher Mosby
ISSN/ISBN 0022-3476 ; 1097-6833
edoc-URL https://edoc.unibas.ch/64018/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jpeds.2013.09.034
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24161220
ISI-Number WOS:000330122900012
Document type (ISI) Journal Article
 
   

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