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Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3887855
Author(s) Kiene, Klara; Porta, Fabiola; Topacogullari, Buket; Detampel, Pascal; Huwyler, Jörg
Author(s) at UniBasel Huwyler, Jörg
Kiene, Klara
Porta, Fabiola
Detampel, Pascal
Year 2017
Title Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins
Journal Journal of Applied Polymer Science
Volume 135
Number 1
Pages / Article-Number 45638
Keywords biomaterials; biomedical applications; biopolymers and renewable polymers; drug-delivery systems; gels
Abstract The development of a self-assembling hydrogel, prepared from maleimide-modified and thiolated chitosan (CS), is described. Under mild reaction conditions, the natural CS polymer was coupled with either maleimide or sulfhydryl moieties in a one-step synthesis. Subsequently, these CS polymers spontaneously formed a covalently crosslinked CS hydrogel when mixed. The three-dimensional network structure was visualized with scanning electron microscopy. The swelling and degradation behavior was evaluated, and viscosity measurements were conducted. The gel was loaded with the model protein albumin, and prolonged release was achieved. These properties were preserved after lyophilization and rehydration. This makes the hydrogel a promising scaffold for biological wound dressings for the treatment of chronic wounds.
Publisher Wiley
ISSN/ISBN 0021-8995 ; 1097-4628
edoc-URL http://edoc.unibas.ch/55900/
Full Text on edoc No
Digital Object Identifier DOI 10.1002/app.45638
ISI-Number 000411491400008
 
   

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17/06/2024