3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei infected mice when administered perorally
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3887659
Author(s) Leven, Michael; Knaab, Tanja C.; Held, Jana; Duffy, Sandra; Meister, Stephan; Fischli, Christoph; Meitzner, Diane; Lehmann, Ursula; Lungerich, Beate; Kuna, Krystina; Stahlke, Petra; Delves, Michael J.; Buchholz, Mirko; Winzeler, Elizabeth A.; Avery, Vicky M.; Mordmüller, Benjamin; Wittlin, Sergio; Kurz, Thomas
Author(s) at UniBasel Wittlin, Sergio
Lehmann, Ursula
Year 2017
Title 3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei infected mice when administered perorally
Journal Journal of Medicinal Chemistry
Volume 60
Number 14
Pages / Article-Number 6036-6044
Abstract Structural optimization of 3-hydroxy-N'-arylidenepropanehydrazonamides provided new analogs with nanomolar to subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent parasite selectivity, and nanomolar activity against the earliest forms of gametocyte development. Particularly, derivatives with a 1,3-dihalo-6-trifluoromethylphenanthrene moiety showed outstanding in vivo properties and demonstrated in part curative activity in the Plasmodium berghei mouse model when administered perorally.
Publisher American Chemical Society
ISSN/ISBN 0022-2623 ; 1520-4804
edoc-URL http://edoc.unibas.ch/55876/
Full Text on edoc No
Digital Object Identifier DOI 10.1021/acs.jmedchem.7b00140
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28653845
ISI-Number WOS:000406727700006
Document type (ISI) Journal Article
 
   

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