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Intracellular Salmonella metabolism
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3871047
Author(s) Bumann, Dirk; Schothorst, Joep
Author(s) at UniBasel Bumann, Dirk
Schothorst, Joep
Year 2017
Title Intracellular Salmonella metabolism
Journal Cellular Microbiology
Volume 19
Number 10
Pages / Article-Number e12766
Abstract Growth of Salmonella inside infected host cells is a key aspect of their ability to cause local enteritis or systemic disease. This growth depends on exploitation of host nutrients through a large Salmonella metabolism network with hundreds of metabolites and enzymes. Studies in cell culture infection models are unraveling more and more of the underlying molecular and cellular mechanisms, but also show striking Salmonella metabolic plasticity depending on host cell line and experimental conditions. In vivo studies have revealed a qualitatively diverse, but quantitatively poor, host-Salmonella nutritional interface, which on one side makes Salmonella fitness largely resilient against metabolic perturbations, but on the other side severely limits Salmonella biomass generation and growth rates. This review discusses goals and techniques for studying Salmonella intracellular metabolism, summarizes main results and implications, and proposes key issues that could be addressed in future studies.
Publisher Wiley
ISSN/ISBN 1462-5814 ; 1462-5822
edoc-URL http://edoc.unibas.ch/55651/
Full Text on edoc Available
Digital Object Identifier DOI 10.1111/cmi.12766
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28672057
 
   

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