Evolutionary Convergence and Divergence in NLR Function and Structure

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Evolutionary Convergence and Divergence in NLR Function and Structure

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3848030
Author(s)	Meunier, Etienne; Broz, Petr
Author(s) at UniBasel	Broz, Petr Meunier, Etienne
Year	2017
Title	Evolutionary Convergence and Divergence in NLR Function and Structure
Journal	Trends in Immunology
Volume	38
Number	10
Pages / Article-Number	744-757
Abstract	The recognition of cellular damage caused by either pathogens or abiotic stress is essential for host defense in all forms of life in the plant and animal kingdoms. The NOD-like receptors (NLRs) represent a large family of multidomain proteins that were initially discovered for their role in host defense in plants and vertebrates. Over recent years the wide distribution of NLRs among metazoans has become apparent and their origins have begun to emerge. Moreover, intense study of NLR function has shown that they play essential roles beyond pathogen recognition - in the regulation of antigen presentation, cell death, inflammation, and even in embryonic development. We summarize here the latest insights into NLR biology and discuss examples of converging and diverging evolution of NLR function and structure.
Publisher	Elsevier
ISSN/ISBN	1471-4906 ; 1471-4981
edoc-URL	http://edoc.unibas.ch/55438/
Full Text on edoc	No
Digital Object Identifier DOI	10.1016/j.it.2017.04.005
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/28579324
ISI-Number	WOS:000411882600007
Document type (ISI)	Journal Article, Review

29/04/2024

Research Database / FORSCHUNGSDATENBANK