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Absolute values of lung function explain the sex difference in breathlessness in the general population
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3844634
Author(s) Ekström, Magnus; Schiöler, Linus; Grřnseth, Rune; Johannessen, Ane; Svanes, Cecilie; Leynaert, Benedicte; Jarvis, Deborah; Gislason, Thorarinn; Demoly, Pascal; Probst-Hensch, Nicole; Pin, Isabelle; Corsico, Angelo G.; Forsberg, Bertil; Heinrich, Joachim; Nowak, Dennis; Raherison-Semjen, Chantal; Dharmage, Shyamali C.; Trucco, Giulia; Urrutia, Isabel; Martinez-Moratalla Rovira, Jesús; Sánchez-Ramos, José Luis; Janson, Christer; Torén, Kjell
Author(s) at UniBasel Probst Hensch, Nicole
Year 2017
Title Absolute values of lung function explain the sex difference in breathlessness in the general population
Journal The European respiratory journal
Volume 49
Number 5
Pages / Article-Number 1602047
Abstract Activity-related breathlessness is twice as common among females as males in the general population and is associated with adverse health outcomes. We tested whether this sex difference is explained by the lower absolute forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) in females.This was a cross-sectional analysis of 3250 subjects (51% female) aged 38-67 years across 13 countries in the population-based third European Community Respiratory Health Survey. Activity-related breathlessness was measured using the modified Medical Research Council (mMRC) scale. Associations with mMRC were analysed using ordered logistic regression clustering on centre, adjusting for post-bronchodilator spirometry, body mass index, pack-years smoking, cardiopulmonary diseases, depression and level of exercise.Activity-related breathlessness (mMRC ≥1) was twice as common in females (27%) as in males (14%) (odds ratio (OR) 2.21, 95% CI 1.79-2.72). The sex difference was not reduced when controlling for FEV1 % predicted (OR 2.33), but disappeared when controlling for absolute FEV1 (OR 0.89, 95% CI 0.69-1.14). Absolute FEV1 explained 98-100% of the sex difference adjusting for confounders. The effect was similar within males and females, when using FVC instead of FEV1 and in healthy never-smokers.The markedly more severe activity-related breathlessness among females in the general population is explained by their smaller spirometric lung volumes.
Publisher Munksgaard
ISSN/ISBN 0903-1936
Full Text on edoc No
Digital Object Identifier DOI 10.1183/13993003.02047-2016
PubMed ID
ISI-Number MEDLINE:28546280
Document type (ISI) Journal Article, Multicenter Study

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