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The exposome in practice : design of the EXPOsOMICS project
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3829070
Author(s) Vineis, P.; Chadeau-Hyam, M.; Gmuender, H.; Gulliver, J.; Herceg, Z.; Kleinjans, J.; Kogevinas, M.; Kyrtopoulos, S.; Nieuwenhuijsen, M.; Phillips, D. H.; Probst-Hensch, N.; Scalbert, A.; Vermeulen, R.; Wild, C. P.; ExposOmics Consortium,
Author(s) at UniBasel Probst Hensch, Nicole
Year 2017
Title The exposome in practice : design of the EXPOsOMICS project
Journal International journal of hygiene and environmental health
Volume 220
Number 2
Pages / Article-Number 142-151
Abstract EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).
Publisher Elsevier
ISSN/ISBN 1438-4639
edoc-URL http://edoc.unibas.ch/55145/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ijheh.2016.08.001
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27576363
ISI-Number WOS:000401215200019
Document type (ISI) Article
 
   

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