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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3826983
Author(s) Wain, Louise V.; Shrine, Nick; Artigas, María Soler; Erzurumluoglu, A. Mesut; Noyvert, Boris; Bossini-Castillo, Lara; Obeidat, Ma'en; Henry, Amanda P.; Portelli, Michael A.; Hall, Robert J.; Billington, Charlotte K.; Rimington, Tracy L.; Fenech, Anthony G.; John, Catherine; Blake, Tineka; Jackson, Victoria E.; Allen, Richard J.; Prins, Bram P.; Understanding Society Scientific Group,; Campbell, Archie; Porteous, David J.; Jarvelin, Marjo-Riitta; Wielscher, Matthias; James, Alan L.; Hui, Jennie; Wareham, Nicholas J.; Zhao, Jing Hua; Wilson, James F.; Joshi, Peter K.; Stubbe, Beate; Rawal, Rajesh; Schulz, Holger; Imboden, Medea; Probst-Hensch, Nicole M.; Karrasch, Stefan; Gieger, Christian; Deary, Ian J.; Harris, Sarah E.; Marten, Jonathan; Rudan, Igor; Enroth, Stefan; Gyllensten, Ulf; Kerr, Shona M.; Polasek, Ozren; Kähönen, Mika; Surakka, Ida; Vitart, Veronique; Hayward, Caroline; Lehtimäki, Terho; Raitakari, Olli T.; Evans, David M.; Henderson, A. John; Pennell, Craig E.; Wang, Carol A.; Sly, Peter D.; Wan, Emily S.; Busch, Robert; Hobbs, Brian D.; Litonjua, Augusto A.; Sparrow, David W.; Gulsvik, Amund; Bakke, Per S.; Crapo, James D.; Beaty, Terri H.; Hansel, Nadia N.; Mathias, Rasika A.; Ruczinski, Ingo; Barnes, Kathleen C.; Bossé, Yohan; Joubert, Philippe; van den Berge, Maarten; Brandsma, Corry-Anke; Paré, Peter D.; Sin, Don D.; Nickle, David C.; Hao, Ke; Gottesman, Omri; Dewey, Frederick E.; Bruse, Shannon E.; Carey, David J.; Kirchner, H. Lester; Jonsson, Stefan; Thorleifsson, Gudmar; Jonsdottir, Ingileif; Gislason, Thorarinn; Stefansson, Kari; Schurmann, Claudia; Nadkarni, Girish; Bottinger, Erwin P.; Loos, Ruth J. F.; Walters, Robin G.; Chen, Zhengming; Millwood, Iona Y.; Vaucher, Julien; Kurmi, Om P.; Li, Liming; Hansell, Anna L.; Brightling, Chris; Zeggini, Eleftheria; Cho, Michael H.; Silverman, Edwin K.; Sayers, Ian; Trynka, Gosia; Morris, Andrew P.; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.
Author(s) at UniBasel Imboden, Medea
Probst Hensch, Nicole
Year 2017
Title Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Journal Nature genetics
Volume 49
Number 3
Pages / Article-Number 416-425
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications.
Publisher Nature Publ
ISSN/ISBN 1061-4036
Full Text on edoc No
Digital Object Identifier DOI 10.1038/ng.3787
PubMed ID
Document type (ISI) Journal Article

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