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Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3775701
Author(s) Müller, Ivan; Beyleveld, Lindsey; Gerber, Markus; Pühse, Uwe; du Randt, Rosa; Utzinger, Jürg; Zondie, Leyli; Walter, Cheryl; Steinmann, Peter
Author(s) at UniBasel Müller, Ivan
Utzinger, Jürg
Steinmann, Peter
Pühse, Uwe
Gerber, Markus
Year 2016
Title Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa
Journal Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume 110
Number 11
Pages / Article-Number 676-678
Abstract Background: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. Methods: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg). Results: Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%). Conclusions: Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
Publisher Oxford University Press
ISSN/ISBN 0035-9203 ; 1878-3503
edoc-URL http://edoc.unibas.ch/54801/
Full Text on edoc No
Digital Object Identifier DOI 10.1093/trstmh/trw075
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28039389
ISI-Number WOS:000398390800009
Document type (ISI) Journal Article
 
   

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