Memory CD8 T cells form the cellular basis for accelerated protection upon re-exposure to the same pathogen, which is a hallmark of adaptive immunity. Reprogramming of metabolic pathways in activated memory T cells is intricately linked to their function. The metabolic basis enabling augmented immune function of memory CD8 T cells during re-infection remains ill explored. Nutrient abundance in the extracellular milieu is altered during infection. How metabolite alterations in the microenvironment influence memory CD8 T cell responses has not been sufficiently investigated.We recently identified both serine and glucose as critical determinants of the CD8 T cell memory response, in vitro and in vivo. We now wish to define how serine and glucose metabolism impacts the CD8 T cell memory response at the organismal, cellular, biochemical, subcellular, and transcriptional level.