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The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3771442
Author(s) Campbell, B.; Raherison, C.; Lodge, C. J.; Lowe, A. J.; Gislason, T.; Heinrich, J.; Sunyer, J.; Gómez Real, F.; Norbäck, D.; Matheson, M. C.; Wjst, M.; Dratva, J.; de Marco, R.; Jarvis, D.; Schlünssen, V.; Janson, C.; Leynaert, B.; Svanes, C.; Dharmage, S. C.
Author(s) at UniBasel Dratva, Julia
Year 2017
Title The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study
Journal Thorax
Volume 72
Number 3
Pages / Article-Number 236-244
Abstract Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.; To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.; The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.; As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.; This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.
Publisher British Medical Association
ISSN/ISBN 0040-6376
edoc-URL http://edoc.unibas.ch/54724/
Full Text on edoc No
Digital Object Identifier DOI 10.1136/thoraxjnl-2015-208154
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27672121
ISI-Number WOS:000394447800013
Document type (ISI) Article
 
   

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23/02/2024