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Motor control of Drosophila feeding behavior
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3750249
Author(s) Schwarz, Olivia; Bohra, Ali Asgar; Liu, Xinyu; Reichert, Heinrich; VijayRaghavan, Krishnaswamy; Pielage, Jan
Author(s) at UniBasel Reichert, Heinrich
Year 2017
Title Motor control of Drosophila feeding behavior
Journal eLife
Volume 6
Pages / Article-Number e19892
Abstract The precise coordination of body parts is essential for survival and behavior of higher organisms. While progress has been made towards the identification of central mechanisms coordinating limb movement, only limited knowledge exists regarding the generation and execution of sequential motor action patterns at the level of individual motoneurons. Here we use Drosophila proboscis extension as a model system for a reaching-like behavior. We first provide a neuroanatomical description of the motoneurons and muscles contributing to proboscis motion. Using genetic targeting in combination with artificial activation and silencing assays we identify the individual motoneurons controlling the five major sequential steps of proboscis extension and retraction. Activity-manipulations during naturally evoked proboscis extension show that orchestration of serial motoneuron activation does not rely on feed-forward mechanisms. Our data support a model in which central command circuits recruit individual motoneurons to generate task-specific proboscis extension sequences.
Publisher eLife Sciences Publications
ISSN/ISBN 2050-084X
edoc-URL http://edoc.unibas.ch/54469/
Full Text on edoc Available
Digital Object Identifier DOI 10.7554/eLife.19892
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/28211791
ISI-Number WOS:000395171500001
Document type (ISI) Journal Article
 
   

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