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Antileishmanial activity of selected South African plant species
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3749222
Author(s) Bapela, M. J.; Kaiser, M.; Meyer, J. J. M.
Author(s) at UniBasel Kaiser, Marcel
Year 2017
Title Antileishmanial activity of selected South African plant species
Journal South African journal of botany
Volume 108
Pages / Article-Number 342-345
Abstract In vitro screening of forty extracts prepared from selected South African plant species was conducted against Leishmania donovani (MHOM-ET-67/L82). Crude plant extracts were also subjected to an antiproliferative bioassay in an attempt to determine their potential lethality or safe therapeutic application against rat skeletal myoblast L6 cells. Of all the tested plant species, only 10% exhibited significant leishmanicidal activity with acceptable SI values (SI >= 10). The current study is the first scientific account on the significant antileishmanial activity (IC50 <= 5 mu g/ml) of Bridelia mollis (Phyllanthaceae), Vangueria infausta subsp. infausta (Rubiaceae), Syzygium cordatum (Myrtaceae) and Xylopia parviflora (Annonaceae). Further phytochemical investigations are currently underway in an attempt to isolate and identify the chemical constituents that may be attributable to the leishmanicidal efficacy observed in the study. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.
Publisher Elsevier
ISSN/ISBN 0254-6299
edoc-URL http://edoc.unibas.ch/54419/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.sajb.2016.08.014
ISI-Number WOS:000390671400047
Document type (ISI) Article
 
   

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