Prenatal and postnatal medical conditions and the risk of brain tumors in children and adolescents : an international multicenter case-control study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
3748867
Author(s)
Tettamanti, Giorgio; Shu, Xiaochen; Adel Fahmideh, Maral; Schüz, Joachim; Röösli, Martin; Tynes, Tore; Grotzer, Michael; Johansen, Christoffer; Klaeboe, Lars; Kuehni, Claudia E.; Lannering, Birgitta; Schmidt, Lisbeth S.; Vienneau, Danielle; Feychting, Maria
Author(s) at UniBasel
Vienneau, Danielle Röösli, Martin
Year
2017
Title
Prenatal and postnatal medical conditions and the risk of brain tumors in children and adolescents : an international multicenter case-control study
Journal
Cancer epidemiology biomarkers & prevention
Volume
26
Number
1
Pages / Article-Number
110-115
Abstract
Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans.; Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-to-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n = 352). The cases were matched by age, sex, and region to 646 population-based controls.; Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity.; Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head.; We have presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs. Cancer Epidemiol Biomarkers Prev; 26(1); 110-5. ©2016 AACR.
Publisher
American Association for Cancer Research
ISSN/ISBN
1055-9965
edoc-URL
http://edoc.unibas.ch/61121/
Full Text on edoc
No
Digital Object Identifier DOI
10.1158/1055-9965.EPI-16-0451
PubMed ID
http://www.ncbi.nlm.nih.gov/pubmed/27624640
ISI-Number
WOS:000393753700016
Document type (ISI)
Journal Article, Multicenter Study
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