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The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant : the SAPALDIA cohort
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3748674
Author(s) Adam, Martin; Imboden, Medea; Schaffner, Emmanuel; Boes, Eva; Kronenberg, Florian; Pons, Marco; Bettschart, Robert; Barthelemy, Jean-Claude; Schindler, Christian; Probst-Hensch, Nicole
Author(s) at UniBasel Adam, Martin
Imboden, Medea
Schaffner, Emmanuel
Schindler, Christian
Probst Hensch, Nicole
Year 2017
Title The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant : the SAPALDIA cohort
Journal International journal of cardiology
Volume 228
Pages / Article-Number 341-346
Abstract Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a genetic variation in a major anti-inflammatory marker gene, NFE2L2, on the relationship between overweight and HRV.; We analyzed participants of the SAPALDIA cohort aged 50years and older, twice in 2002/2003 (N=1472) and 2010/2011 (N=1235). We included persons with valid genotype data, who underwent ambulatory 24-h electrocardiogram monitoring, and reported on medical history and lifestyle. The association between HRV and BMI, measured as standard deviation of normal-to-normal intervals (SDNN) by BMI and the modifying effect of the cardiovascular health-related NFE2L2 gene variant rs2364723 were tested, applying multivariable mixed linear regression models.; We found study participants with overweight (BMI>25) over two follow-up surveys 10years apart to have a negative association between SDNN, calculated as geometric means, with BMI. The examined NFE2L2 variant sustainably modified (pinteraction=0.014) the found inverse association between a BMI increment and SDNN, causing a stronger decrement in SDNN for participants with the CC genotype (-20.7%; 95%-confidence interval: -12.33 to -28.28) compared with participants carrying the GC (-7.43; 95%CI: -3.56 to -11.15) or GG (-11.26%; 95%CI: -7.68 to -14.7) genotype, estimated for the difference from the 90(th) to the 10(th) percentile of BMI by the NFE2L2 variant.; Our results are consistent with the hypothesis that overweight decreases heart rate variability through inflammatory processes.
Publisher Excerpta medica
ISSN/ISBN 0167-5273
edoc-URL http://edoc.unibas.ch/54361/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ijcard.2016.11.049
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27866025
ISI-Number WOS:000393408600056
Document type (ISI) Article
 
   

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