Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

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Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3728466
Author(s)	Yang, Lei; Melot, Romain; Neuburger, Markus; Baudoin, Olivier
Author(s) at UniBasel	Yang, Lei Melot, Romain Neuburger, Markus Baudoin, Olivier
Year	2017
Year: comment	2016
Title	Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand
Journal	Chemical Science
Volume	8
Number	2
Pages / Article-Number	1344-1349
Abstract	The first efficient palladium(0)-catalyzed enantioselective C(sp 3 )–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.
Publisher	Royal Society of Chemistry
ISSN/ISBN	2041-6520 ; 2041-6539
edoc-URL	http://edoc.unibas.ch/53920/
Full Text on edoc	Available
Digital Object Identifier DOI	10.1039/C6SC04006C

29/04/2024

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