Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds

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Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3728463
Author(s)	Duret, Guillaume; Quinlan, Robert; Martin, Rainer E.; Bisseret, Philippe; Neuburger, Markus; Grandon, Vincent; Blanchard, Nicolas
Author(s) at UniBasel	Neuburger, Markus
Year	2016
Year: comment	2016
Title	Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds
Journal	Organic Letters
Volume	18
Number	7
Pages / Article-Number	1610-3
Abstract	Functionalized polycyclic aminopyridines are central to the chemical sciences, but their syntheses are still hampered by a number of shortcomings. These nitrogenated heterocycles can be efficiently prepared by an intramolecular inverse electron demand hetero Diels–Alder ( ih DA) cycloaddition of ynamides to pyrimidines. This ihDA/rDA sequence is general in scope and affords expedient access to novel types of aminopyridinyl scaffolds that hold great promise in terms of exit vector patterns.
Publisher	American Chemical Society
ISSN/ISBN	1523-7060 ; 1523-7052
edoc-URL	http://edoc.unibas.ch/53919/
Full Text on edoc	Available
Digital Object Identifier DOI	10.1021/acs.orglett.6b00464
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/26998920
ISI-Number	WOS:000373519600029
Document type (ISI)	Journal Article

29/04/2024

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