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Antipsychotics decrease response confidence
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3726626
Author(s) Moritz, Steffen; Kolbeck, Katharina; Andreou, Christina
Author(s) at UniBasel Andreou, Christina
Year 2016
Title Antipsychotics decrease response confidence
Journal Journal of Psychopharmacology
Volume 30
Number 8
Pages / Article-Number 831-3
Abstract Antipsychotics represent the first-choice treatment for schizophrenia. However, the cognitive and emotional pathways through which symptom reduction is achieved have remained unclear. We recently proposed that the induction of doubt is a core mechanism of action of antipsychotics. In the framework of a randomized, double-blind, placebo-controlled, crossover design, 39 nonclinical participants filled out a questionnaire tapping into cognitive and emotional changes (Effect of Antipsychotic Medication on Emotion and Cognition-revised (EAMEC-r)) each time they had received one of three substances (haloperidol, placebo, L-dopa). Participants reported more doubt under haloperidol than under L-dopa lending support to the theory that antipsychotics decrease delusional conviction via the reduction of confidence. Key points from this study are: (a) antipsychotics induce doubt, and (b) doubt may represent a core mechanism of action for the reduction of delusional ideas.
Publisher SAGE Publications
ISSN/ISBN 0269-8811 ; 1461-7285
edoc-URL http://edoc.unibas.ch/53816/
Full Text on edoc No
Digital Object Identifier DOI 10.1177/0269881116650404
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27222269
ISI-Number WOS:000381028200009
Document type (ISI) Journal Article
 
   

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