Alterations of consciousness and mystical-type experiences after acute LSD in humans
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3720773
Author(s) Liechti, Matthias E.; Dolder, Patrick C.; Schmid, Yasmin
Author(s) at UniBasel Liechti, Matthias Emanuel
Year 2017
Title Alterations of consciousness and mystical-type experiences after acute LSD in humans
Journal Psychopharmacology
Volume 234
Number 9-10
Pages / Article-Number 1499-1510
Keywords Altered states of consciousness; Lsd; Mystical experiences
Mesh terms Adult; Consciousness, physiology; Consciousness Disorders, psychology; Cross-Over Studies; Double-Blind Method; Female; Hallucinogens, blood; Healthy Volunteers; Humans; Lysergic Acid Diethylamide, blood; Male; Middle Aged; Mysticism, psychology; Surveys and Questionnaires; Switzerland
Abstract Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. Acute mystical-type experiences that are acutely induced by hallucinogens are thought to contribute to their potential therapeutic effects. However, no data have been reported on LSD-induced mystical experiences and their relationship to alterations of consciousness. Additionally, LSD dose- and concentration-response functions with regard to alterations of consciousness are lacking.; We conducted two placebo-controlled, double-blind, cross-over studies using oral administration of 100 and 200 μg LSD in 24 and 16 subjects, respectively. Acute effects of LSD were assessed using the 5 Dimensions of Altered States of Consciousness (5D-ASC) scale after both doses and the Mystical Experience Questionnaire (MEQ) after 200 μg.; On the MEQ, 200 μg LSD induced mystical experiences that were comparable to those in patients who underwent LSD-assisted psychotherapy but were fewer than those reported for psilocybin in healthy subjects or patients. On the 5D-ASC scale, LSD produced higher ratings of blissful state, insightfulness, and changed meaning of percepts after 200 μg compared with 100 μg. Plasma levels of LSD were not positively correlated with its effects, with the exception of ego dissolution at 100 μg.; Mystical-type experiences were infrequent after LSD, possibly because of the set and setting used in the present study. LSD may produce greater or different alterations of consciousness at 200 μg (i.e., a dose that is currently used in psychotherapy in Switzerland) compared with 100 μg (i.e., a dose used in imaging studies). Ego dissolution may reflect plasma levels of LSD, whereas more robustly induced effects of LSD may not result in such associations.
Publisher Springer
ISSN/ISBN 0033-3158 ; 1432-2072
Full Text on edoc Available
Digital Object Identifier DOI 10.1007/s00213-016-4453-0
PubMed ID
ISI-Number WOS:000400855400014
Document type (ISI) Journal Article

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