Ageing with HIV: medication use and risk for potential drug-drug interactions
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3704455
Author(s) Marzolini, Catia; Back, David; Weber, Rainer; Furrer, Hansjakob; Cavassini, Matthias; Calmy, Alexandra; Vernazza, Pietro; Bernasconi, Enos; Khoo, Saye; Battegay, Manuel; Elzi, Luigia; Swiss HIV Cohort Study Members,
Author(s) at UniBasel Marzolini, Catia
Year 2011
Title Ageing with HIV: medication use and risk for potential drug-drug interactions
Journal The journal of antimicrobial chemotherapy
Volume 66
Number 9
Pages / Article-Number 2107-11
Mesh terms Adult; Aged; Aging, physiology; Anti-HIV Agents, therapeutic use; Antiretroviral Therapy, Highly Active, adverse effects; Cardiovascular Agents, therapeutic use; Central Nervous System Agents, therapeutic use; Cohort Studies; Drug Interactions; Drug Prescriptions, statistics & numerical data; Female; Follow-Up Studies; Gastrointestinal Agents, therapeutic use; HIV Infections, virology; Hormones, therapeutic use; Humans; Male; Methadone, therapeutic use; Middle Aged; Narcotics, therapeutic use; Socioeconomic Factors; Substance Abuse, Intravenous, complications; Substance-Related Disorders, complications; Switzerland, epidemiology
Abstract To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years.; All ART-treated participants were prospectively included once during a follow-up visit of the Swiss HIV Cohort Study. Information on any current medication was obtained by participant self-report and medical prescription history. The complete treatment was subsequently screened for PDDIs using a customized version of the Liverpool drug interaction database.; Drug prescriptions were analysed for 1497 HIV-infected individuals: 477 age ≥ 50 and 1020 age <50. Older patients were more likely to receive one or more co-medications compared with younger patients (82% versus 61%; P < 0.001) and thus had more frequent PDDIs (51% versus 35%; P < 0.001). Furthermore, older patients tended to use a higher number of co-medications and certain therapeutic drug classes more often, such as cardiovascular drugs (53% versus 19%; P < 0.001), gastrointestinal medications (10% versus 6%; P = 0.004) and hormonal agents (6% versus 3%; P = 0.04). PDDIs with ART occurred mainly with cardiovascular drugs (27%), CNS agents (22%) and methadone (6%) in older patients and with CNS agents (27%), methadone (15%) and cardiovascular drugs (11%) in younger patients. The response to ART did not differ between the two groups.; The risk for PDDIs with ART increased in older patients who take more drugs than their younger HIV-infected counterparts. However, medication use in older and younger patients did not differ in terms of effect on antiretroviral tolerability and response.
Publisher Oxford University Press
ISSN/ISBN 0305-7453 ; 1460-2091
Full Text on edoc No
Digital Object Identifier DOI 10.1093/jac/dkr248
PubMed ID
ISI-Number WOS:000293917000029
Document type (ISI) Journal Article

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