A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites

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A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3704131
Author(s)	Thamm, Irene; Richers, Johannes; Rychlik, Michael; Tiefenbacher, Konrad
Author(s) at UniBasel	Tiefenbacher, Konrad
Year	2016
Title	A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites
Journal	Chemical Communications
Volume	52
Number	78
Pages / Article-Number	11701-11703
Abstract	The short synthesis of alpha-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d(6)-acetone can be used as a starting material, the route developed allows for the facile incorporation of isotopic labels which are required for detecting and quantifying trace amounts via GC/MS analysis.
Publisher	Royal Society of Chemistry
ISSN/ISBN	1359-7345 ; 1364-548X
edoc-URL	http://edoc.unibas.ch/52651/
Full Text on edoc	Available
Digital Object Identifier DOI	10.1039/c6cc05376a
ISI-Number	000385475700021
Document type (ISI)	Article

24/04/2024

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