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Antiplasmodial lanostanes from the Ganoderma lucidum mushroom
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 370091
Author(s) Adams, Michael; Christen, Marco; Plitzko, Inken; Zimmermann, Stefanie; Brun, Reto; Kaiser, Marcel; Hamburger, Matthias
Author(s) at UniBasel Hamburger, Matthias
Adams, Michael
Plitzko, Inken
Zimmermann, Stefanie
Brun, Reto
Kaiser, Marcel
Year 2010
Title Antiplasmodial lanostanes from the Ganoderma lucidum mushroom
Journal Journal of Natural Products
Volume 73
Number 5
Pages / Article-Number 897-900
Abstract

In a screen of 880 extracts from plants and fungi for antiplasmodial, antitrypanosomal, and leishmanicidal activity, an ethyl acetate extract of the mushroom Ganoderma lucidum showed antiplasmodial activity with 79% inhibition at 4.9 microg/mL. HPLC-based activity profiling and subsequent isolation of the antiplasmodial compounds yielded seven lanostanes (1-7), of which three (2, 3, and 7) were new. A new benzofuran derivative (8) of the farnesyl hydroquinone ganomycin B was also identified. The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. The lanostanes exhibited in vitro antiplasmodial activity with IC(50) values from 6 to greater than 20 microM

Publisher American Society of Pharmacognosy
ISSN/ISBN 0163-3864
edoc-URL http://edoc.unibas.ch/dok/A5843077
Full Text on edoc No
Digital Object Identifier DOI 10.1021/np100031c
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20384295
ISI-Number WOS:000278080900019
Document type (ISI) Journal Article
 
   

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