Molecular engineering of polymersome surface topology

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Molecular engineering of polymersome surface topology

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	3697837
Author(s)	Ruiz-Pérez, Lorena; Messager, Lea; Gaitzsch, Jens; Joseph, Adrian; Sutto, Ludovico; Gervasio, Francesco Luigi; Battaglia, Giuseppe
Author(s) at UniBasel	Meier, Wolfgang P.
Year	2016
Title	Molecular engineering of polymersome surface topology
Journal	Science Advances
Volume	2
Number	4
Pages / Article-Number	e1500948
Abstract	Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined interactions. We report polymersomes with patterns that emerge by engineering interfacial tension within the polymersome surface. This allows the formation of domains whose topology is tailored by chemical synthesis, paving the avenue to complex supramolecular designs functionally similar to those found in viruses and trafficking vesicles.
Publisher	American Association for the Advancement of Science
ISSN/ISBN	2375-2548
edoc-URL	http://edoc.unibas.ch/52100/
Full Text on edoc	Available
Digital Object Identifier DOI	10.1126/sciadv.1500948
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/27152331
ISI-Number	000380072100005
Document type (ISI)	Journal Article

03/05/2024

Research Database / FORSCHUNGSDATENBANK