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Particulate matter and subclinical atherosclerosis : associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3657306
Author(s) Aguilera, Inmaculada; Dratva, Julia; Caviezel, Seraina; Burdet, Luc; de Groot, Eric; Ducret-Stich, Regina E.; Eeftens, Marloes; Keidel, Dirk; Meier, Reto; Perez, Laura; Rothe, Thomas; Schaffner, Emmanuel; Schmit-Trucksäss, Arno; Tsai, Ming-Yi; Schindler, Christian; Künzli, Nino; Probst-Hensch, Nicole
Author(s) at UniBasel Künzli, Nino
Schindler, Christian
Probst Hensch, Nicole
Eeftens, Marloes
Dratva, Julia
Perez, Laura
Tsai, Ming-Yi
Schaffner, Emmanuel
Keidel, Dirk
Ducret-Stich, Regina
Caviezel, Seraina
Year 2016
Title Particulate matter and subclinical atherosclerosis : associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study
Journal Environmental Health Perspectives
Volume 124
Number 11
Pages / Article-Number 1700-1706
Abstract Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.; We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).; We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.; The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.; CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.
Publisher National Institute of Environmental Health Sciences
ISSN/ISBN 0091-6765 ; 1552-9924
edoc-URL http://edoc.unibas.ch/44901/
Full Text on edoc Available
Digital Object Identifier DOI 10.1289/EHP161
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27258721
ISI-Number WOS:000386913800013
Document type (ISI) Journal Article
 
   

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18/05/2024