Heart Rate Variability and Sleep-Related Breathing Disorders in the General Population
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3645849
Author(s) Aeschbacher, Stefanie; Bossard, Matthias; Schoen, Tobias; Schmidlin, Delia; Muff, Christoph; Maseli, Anna; Leuppi, Jörg D.; Miedinger, David; Probst-Hensch, Nicole M.; Schmidt-Trucksäss, Arno; Risch, Martin; Risch, Lorenz; Conen, David
Author(s) at UniBasel Probst Hensch, Nicole
Schmidt-Trucksäss, Arno
Year 2016
Title Heart Rate Variability and Sleep-Related Breathing Disorders in the General Population
Journal The American Journal of Cardiology
Volume 118
Number 6
Pages / Article-Number 912-917
Abstract Obstructive sleep apnea seems to have an important influence on the autonomic nervous system. In this study, we assessed the relations of sleep apnea-related parameters with 24-hour heart rate variability (HRV) in a large population of young and healthy adults. Participants aged 25 to 41 years with a body mass index <35 kg/m(2) and without known obstructive sleep apnea were included in a prospective population-based cohort study. HRV was assessed using 24-hour electrocardiographic monitoring. The SD of all normal RR intervals (SDNN) was used as the main HRV variable. Apnea-Hypopnea Index (AHI) and oxygen desaturation index (ODI) were obtained from nighttime pulse oximetry with nasal airflow measurements. We defined sleep-related breathing disorders as an AHI ≥5 or an ODI ≥5. Multivariable regression models were constructed to assess the relation of HRV with either AHI or ODI. Median age of the 1,255 participants was 37 years, 47% were men, and 9.6% had an AHI ≥5. Linear inverse associations of SDNN across AHI and ODI groups were found (p for trend = 0.006 and 0.0004, respectively). The β coefficients (95% CI) for the relation between SDNN and elevated AHI were -0.20 (-0.40 to -0.11), p = 0.04 and -0.29 (-0.47 to -0.11), p = 0.002 for elevated ODI. After adjustment for 24-hour heart rate, the same β coefficients (95% CI) were -0.06 (-0.22 to 0.11), p = 0.51 and -0.14 (-0.30 to 0.01), p = 0.07, respectively. In conclusion, even early stages of sleep-related breathing disorders are inversely associated with HRV in young and healthy adults, suggesting that they are tightly linked with autonomic dysfunction. However, HRV and 24-hour heart rate seem to have common information.
Publisher Elsevier Science
ISSN/ISBN 0002-9149 ; 1879-1913
edoc-URL http://edoc.unibas.ch/44603/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.amjcard.2016.06.032
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27553103
ISI-Number WOS:000385053300022
Document type (ISI) Journal Article

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