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Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3645228
Author(s) Witzigmann, Dominik; Detampel, Pascal; Porta, Fabiola; Huwyler, Jörg
Author(s) at UniBasel Huwyler, Jörg
Detampel, Pascal
Witzigmann, Dominik
Porta, Fabiola
Year 2016
Title Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor
Journal RSC Advances
Volume 6
Number 100
Pages / Article-Number 97636-97640
Abstract The asialoglycoprotein receptor (ASGPR) expressed on parenchymal liver cells specifically binds multivalent carbohydrates from desialylated glycoproteins. This feature offers a huge potential for hepatocyte specific drug targeting. In this study, multiantennary N-glycans from asialofetuin have been isolated to actively target the asialoglycoprotein receptor on human hepatocellular carcinoma cells in vitro.
Publisher Royal Society of Chemistry
ISSN/ISBN 2046-2069
edoc-URL http://edoc.unibas.ch/44551/
Full Text on edoc No
Digital Object Identifier DOI 10.1039/C6RA18297F
ISI-Number WOS:000386312700019
Document type (ISI) Article
 
   

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