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Analysis of diagnostic findings from the european mobile laboratory in Gueckedou, Guinea, march 2014 through march 2015
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3645194
Author(s) Kerber, Romy; Krumkamp, Ralf; Diallo, Boubacar; Jaeger, Anna; Rudolf, Martin; Lanini, Simone; Bore, Joseph Akoi; Koundouno, Fara Raymond; Becker-Ziaja, Beate; Fleischmann, Erna; Stoecker, Kilian; Meschi, Silvia; Mély, Stéphane; Newman, Edmund N. C.; Carletti, Fabrizio; Portmann, Jasmine; Korva, Misa; Wolff, Svenja; Molkenthin, Peter; Kis, Zoltan; Kelterbaum, Anne; Bocquin, Anne; Strecker, Thomas; Fizet, Alexandra; Castilletti, Concetta; Schudt, Gordian; Ottowell, Lisa; Kurth, Andreas; Atkinson, Barry; Badusche, Marlis; Cannas, Angela; Pallasch, Elisa; Bosworth, Andrew; Yue, Constanze; Pályi, Bernadett; Ellerbrok, Heinz; Kohl, Claudia; Oestereich, Lisa; Logue, Christopher H.; Lüdtke, Anja; Richter, Martin; Ngabo, Didier; Borremans, Benny; Becker, Dirk; Gryseels, Sophie; Abdellati, Saďd; Vermoesen, Tine; Kuisma, Eeva; Kraus, Annette; Liedigk, Britta; Maes, Piet; Thom, Ruth; Duraffour, Sophie; Diederich, Sandra; Hinzmann, Julia; Afrough, Babak; Repits, Johanna; Mertens, Marc; Vitoriano, Inęs; Bah, Amadou; Sachse, Andreas; Boettcher, Jan Peter; Wurr, Stephanie; Bockholt, Sabrina; Nitsche, Andreas; Županc, Tatjana Avšič; Strasser, Marc; Ippolito, Giuseppe; Becker, Stephan; Raoul, Herve; Carroll, Miles W.; De Clerck, Hilde; Van Herp, Michel; Sprecher, Armand; Koivogui, Lamine; Magassouba, N'Faly; Keďta, Sakoba; Drury, Patrick; Gurry, Cčline; Formenty, Pierre; May, Jürgen; Gabriel, Martin; Wölfel, Roman; Günther, Stephan; Di Caro, Antonino
Author(s) at UniBasel Bah, Amadou
Year 2016
Title Analysis of diagnostic findings from the european mobile laboratory in Gueckedou, Guinea, march 2014 through march 2015
Journal Journal of infectious diseases
Volume 214
Number suppl 3
Pages / Article-Number S250-S257
Mesh terms Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Laboratory Services; Ebolavirus, isolation & purification; Epidemics; Female; Filoviridae; Filoviridae Infections, virology; Guinea; Hemorrhagic Fever, Ebola, virology; Humans; Infant; Malaria, parasitology; Male; Middle Aged; Mobile Health Units; RNA, Viral, blood; Viral Load; Young Adult
Abstract A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015.; The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively.; The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome.; Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD.
Publisher Oxford University Press
ISSN/ISBN 0022-1899
edoc-URL https://edoc.unibas.ch/64780/
Full Text on edoc No
Digital Object Identifier DOI 10.1093/infdis/jiw269
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27638946
Document type (ISI) Journal Article
 
   

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29/03/2024