Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3641355
Author(s) Liu, Xiaolong; BoseDasgupta, Somdeb; Jayachandran, Rajesh; Studer, Vera; Rühl, Sebastian; Stiess, Michael; Pieters, Jean
Author(s) at UniBasel Pieters, Jean
Year 2016
Title Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity
Journal FEBS Letters
Volume 590
Number 2
Pages / Article-Number 279-87
Abstract Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Gαs in a stimulus-dependent manner, but the molecular mechanism regulating coronin 1-Gαs interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Gαs association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway.
Publisher Wiley-Blackwell
ISSN/ISBN 0014-5793 ; 1873-3468
edoc-URL http://edoc.unibas.ch/44401/
Full Text on edoc No
Digital Object Identifier DOI 10.1002/1873-3468.12046
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26823173
ISI-Number WOS:000369850300010
Document type (ISI) Journal Article
 
   

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