Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Antiangiogenesis: current clinical data and future perspectives
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3591679
Author(s) Drevs, J.; Laus, C.; Medinger, M.; Schmidt-Gersbach, C.; Unger, C.
Author(s) at UniBasel Medinger, Michael
Year 2002
Title Antiangiogenesis: current clinical data and future perspectives
Journal Onkologie
Volume 25
Number 6
Pages / Article-Number 520-7
Abstract Neovascularization is a prerequisite for progressive growth of solid tumors and their metastases. This process is tightly regulated by a large number of proangiogenic and antiangiogenic factors such as VEGF, bFGF and matrix-metalloproteinases. The inhibition of angiogenesis is an innovative therapeutic approach and could represent a powerful adjunct to traditional therapy of malignant tumors. Preclinical trials have been very successful but in clinical studies meaningful response rates could only be shown in some cases. This might indicate the existence of different angiogenic phenotypes in humans. It seems that at present only a part of the interactions between the angiogenic cytokines are known. In addition, new receptor/ligand systems which regulate the neovascularization are being described. This article presents an overview of the most important angiogenically active substances, preclinical and clinical data, surrogate markers as well as future perspectives.
Publisher Karger Publishers
ISSN/ISBN 0378-584X ; 1423-0240
edoc-URL http://edoc.unibas.ch/43942/
Full Text on edoc Available
Digital Object Identifier DOI 10.1159/000068622
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/12566896
ISI-Number WOS:000180707700005
Document type (ISI) Journal Article, Review
 
   

MCSS v5.8 PRO. 0.329 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024