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Inflammasomes: mechanism of assembly, regulation and signalling
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3542920
Author(s) Broz, Petr; Dixit, Vishva M
Author(s) at UniBasel Broz, Petr
Year 2016
Title Inflammasomes: mechanism of assembly, regulation and signalling
Journal Nature reviews. Immunology
Volume 16
Number 7
Pages / Article-Number 407-20
Abstract Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.
Publisher Nature Publishing Group
ISSN/ISBN 1474-1733
edoc-URL http://edoc.unibas.ch/43417/
Full Text on edoc No
Digital Object Identifier DOI 10.1038/nri.2016.58
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/27291964
ISI-Number WOS:000378837900008
Document type (ISI) Journal Article
 
   

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