Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Anti-staphylococcal prenylated acylphoroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3539152
Author(s) Coqueiro, Aline; Choi, Young H.; Verpoorte, Robert; Sankar Gupta, Karthick B. S.; De Mieri, Maria; Hamburger, Matthias; Marx Young, Maria C.; Stapleton, Paul; Gibbons, Simon; da Silva Bolzani, Vanderlan
Author(s) at UniBasel Hamburger, Matthias
de Mieri, Maria
Year 2016
Title Anti-staphylococcal prenylated acylphoroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae)
Journal Journal of natural products
Volume 79
Number 3
Pages / Article-Number 470-476
Abstract

Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as compared with an MIC of 128 mg/L for the control antibiotic norfloxacin. The structure of the new compound was elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry, and experimental and calculated ECD were used to determine the absolute configurations. The compounds β-sitosterol (2), stigmasterol (3), ergost-5-en-3-ol (4), and osajaxanthone (5) also occurred in the n-hexane fraction. The EtOAc fraction contained nine known xanthones: 3,6-dihydroxy-1,4,8-trimethoxyxanthone (6), 3,5-dihydroxy-4-methoxyxanthone (7), 3,4-dihydroxy-6,8-dimethoxyxanthone (8), 3,4-dihydroxy-2-methoxyxanthone (9), 5-hydroxy-1,3-dimethoxyxanthone (10), 4-hydroxy-2,3-dimethoxyxanthone (11), kielcorin (12), 3-hydroxy-2-methoxyxanthone (13), and 2-hydroxy-1-methoxyxanthone (14), which showed moderate to low activity against the tested MRSA strains.

Publisher American Society of Pharmacognosy
ISSN/ISBN 0163-3864
edoc-URL http://edoc.unibas.ch/43377/
Full Text on edoc No
Digital Object Identifier DOI 10.1021/acs.jnatprod.5b00858
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26900954
ISI-Number WOS:000373031200004
Document type (ISI) Article
 
   

MCSS v5.8 PRO. 0.333 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024