Cost-effectiveness of hyperkalemia treatment
Third-party funded project
Project title Cost-effectiveness of hyperkalemia treatment
Principal Investigator(s) Schwenkglenks, Matthias
Co-Investigator(s) Szucs, Thomas
Project Members Ademi, Zanfina
Sutherland, Claudette Simone
Organisation / Research unit Departement Public Health / Pharmazeutische Medizin (Szucs)
Project start 25.04.2016
Probable end 31.12.2019
Status Completed
Abstract

An increase in blood-serum-potassium levels (hyperkalemia) is common in patients with renal impairment or heart failure. Indicated drug treatments, namely RAAS-inhibitors, (RAASi) such as ACE inhibitors, AT1 receptor-antagonists and aldosterone-blockers, lead to a further rise in potassium levels and may need to be discontinued despite their favourable cardiac and renal effects.

Patiromer is an oral drug that can be used to treat latent/chronic hyperkalemia, reduce the risk of acute episodes of hyperkalemia, and enable the continuation of RAASi treatment.

Based on clinical trial data, published literature and expert input, we have developed a decision-analytic model, composed of a decision-tree and a semi-Markov module, to evaluate the health economic properties of treatment with patiromer, for European countries.

Keywords Cost-effectiveness, hyperkalemia, health economics
Financed by Private Sector / Industry
   

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