Physiology of pro-inflammatory cytokines and islet resident immune cells in insulin secretion
Third-party funded project
Project title Physiology of pro-inflammatory cytokines and islet resident immune cells in insulin secretion
Principal Investigator(s) Donath, Marc
Organisation / Research unit Departement Biomedizin / Diabetes Research (Donath),
Bereich Medizinische Fächer (Klinik) / Endokrinologie, Diabetologie und Metabolismus (Donath)
Project start 01.04.2016
Probable end 31.03.2019
Status Completed
Abstract

The deleterious role of chronic activation of the innate immune system in type 2 diabetes is well documented. However, little attention has been paid to a possible physiological role of the immune system in metabolism. The general objective of the present project is to uncover mechanisms on how the innate immune system contributes to the adaption of pancreatic islet function under various physiological and stressful (obesity and diabetes) situations.

Keywords Diabetes, Inflammation
Financed by Swiss National Science Foundation (SNSF)
   

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