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Proposal of standardization to assess adherence with medication records: methodology matters
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 3472778
Author(s) Arnet, Isabelle; Kooij, Marcel J.; Messerli, Markus; Hersberger, Kurt E.; Heerdink, Eibert R.; Bouvy, Marcel
Author(s) at UniBasel Arnet, Isabelle
Messerli, Markus
Hersberger, Kurt
Year 2016
Title Proposal of standardization to assess adherence with medication records: methodology matters
Journal Annals of Pharmacotherapy
Volume 50
Number 5
Pages / Article-Number 360-368
Keywords adherence, measurements, medication, operationalization, standards
Mesh terms Drug Monitoring, classification; Drug Prescriptions; Electronic Health Records, standards; Humans; Medication Adherence
Abstract Medication adherence is the process by which patients take their medication as prescribed and is an umbrella term that encompasses all aspects of medication use patterns. Ambiguous terminology has emerged to describe a deviation from prescribed regimen, forcing the European ABC Project to define 3 phases of medication use: initiation, implementation, and discontinuation. However, different measures of medication adherence using medication records are currently available that do not always distinguish between these phases. The literature is lacking standardization and operationalization of the assessment methods.; To propose a harmonization of standards as well as definitions of distinct measures and their operationalization to quantify adherence to medication from medication records.; Group discussions and consensus process among all coauthors. The propositions were generated using the authors' experiences and views in the field of adherence, informed by theory.; The concepts of adherence measures within the new taxonomy were harmonized, and the standards necessary for the operationalization of adherence measures from medication records are proposed. Besides percentages and time-to values, the addition of a dichotomous value for the reinitiation of treatment is proposed. Methodological issues are listed that should be disclosed in studies on adherence.; The possible impact of the measures in adherence research is discussed. By doing this, the results of future adherence research should gain in accuracy. Finally, studies will become more transparent, enabling comparison between studies.
Publisher SAGE Publications
ISSN/ISBN 1060-0280
Full Text on edoc Available
Digital Object Identifier DOI 10.1177/1060028016634106
PubMed ID
ISI-Number 000374114700003
Document type (ISI) Article

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