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Identification and characterization of FTY720 for the treatment of human African trypanosomiasis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3446984
Author(s) Jones, Amy J; Kaiser, Marcel; Avery, Vicky M
Author(s) at UniBasel Kaiser, Marcel
Year 2015
Title Identification and characterization of FTY720 for the treatment of human African trypanosomiasis
Journal Antimicrobial agents and chemotherapy
Volume 60
Number 3
Pages / Article-Number 1859-61
Abstract The screening of a focused library identified FTY720 (Fingolimod; Gilenya) as a potent selective antitrypanosomal compound active against Trypanosoma brucei gambiense and T. brucei rhodesiense, the causative agents of human African trypanosomiasis (HAT). This is the first report of trypanocidal activity for FTY720, an oral drug registered for the treatment of relapsing multiple sclerosis, and the characterization of sphingolipids as a potential new class of compounds for HAT.
Publisher American Society for Microbiology
ISSN/ISBN 1098-6596
edoc-URL http://edoc.unibas.ch/42162/
Full Text on edoc No
Digital Object Identifier DOI 10.1128/AAC.02116-15
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26666915
Document type (ISI) Journal Article
 
   

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