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Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3418789
Author(s) Bruderer, Saskia G; Bodmer, Michael; Jick, Susan S; Meier, Christoph R
Author(s) at UniBasel Bruderer, Saskia
Bodmer, Michael
Meier, Christoph R.
Year 2015
Title Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study
Journal Annals of the rheumatic diseases
Volume 74
Number 9
Pages / Article-Number 1651-8
Abstract The aim of this study was to explore the risk of incident gout in patients with type 2 diabetes mellitus (T2DM) in association with diabetes duration, diabetes severity and antidiabetic drug treatment.; We conducted a case-control study in patients with T2DM using the UK-based Clinical Practice Research Datalink (CPRD). We identified case patients aged ≥18 years with an incident diagnosis of gout between 1990 and 2012. We matched to each case patient one gout-free control patient. We used conditional logistic regression analysis to calculate adjusted ORs (adj. ORs) with 95% CIs and adjusted our analyses for important potential confounders.; The study encompassed 7536 T2DM cases with a first-time diagnosis of gout. Compared to a diabetes duration <1 year, prolonged diabetes duration (1-3, 3-6, 7-9 and ≥10 years) was associated with decreased adj. ORs of 0.91 (95% CI 0.79 to 1.04), 0.76 (95% CI 0.67 to 0.86), 0.70 (95% CI 0.61 to 0.86), and 0.58 (95% CI 0.51 to 0.66), respectively. Compared to a reference A1C level of <7%, the risk estimates of increasing A1C levels (7.0-7.9, 8.0-8.9 and ≥9%) steadily decreased with adj. ORs of 0.79 (95% CI 0.72 to 0.86), 0.63 (95% CI 0.55 to 0.72), and 0.46 (95% CI 0.40 to 0.53), respectively. Neither use of insulin, metformin, nor sulfonylureas was associated with an altered risk of incident gout.; Increased A1C levels, but not use of antidiabetic drugs, was associated with a decreased risk of incident gout among patients with T2DM.
Publisher British Medical Association
ISSN/ISBN 0003-4967
edoc-URL http://edoc.unibas.ch/41950/
Full Text on edoc No
Digital Object Identifier DOI 10.1136/annrheumdis-2014-205337
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/24728333
ISI-Number WOS:000359378100012
Document type (ISI) Journal Article
 
   

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