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Hybrid pixel detectors for electron diffraction of nano-samples
Third-party funded project
Project title Hybrid pixel detectors for electron diffraction of nano-samples
Principal Investigator(s) Abrahams, Jan Pieter
Co-Investigator(s) Stahlberg, Henning
Project Members Grüne, Tim
Schmitt, Bernd
Schulze-Briese, Clemens
Organisation / Research unit Faculty of Science,
Departement Biozentrum / Nano-diffraction of Biological Specimen (Abrahams)
Project start 01.01.2016
Probable end 31.12.2016
Status Completed
Abstract

We propose adapting the Eiger hybrid pixel detector developed at PSI and commercialised by the awardwinning
Swiss company Dectris for measuring the atomic structure of nanometer sized samples by free
electron diffraction. Our pilot electron diffraction studies with CERN-developed Timepix hybrid pixel detectors
with an Si sensor, indicate that Eiger detectors with a CdTe or GaAs sensor would ensure a major
improvement in performance. Currently, Eiger detectors also have an Si sensor, like Medipix. The improvements
we propose will allow us to study 3D structures of molecules in atomic detail using only
minute amounts of sample, including crystals of organic compounds that are only 20 nm in size. This will
be a significant step forwards in mastering the molecular world at the sub-nanometer scale.
We will build an Eiger detector into a 300 kV electron microscope, and quantify its parameters for highenergy
electron detection (DQE as a function of resolution and dose). We will investigate how to optimally
combine the Eiger design with a high Z sensor (GaAs or CdTe). We will validate our results in structural
studies of weakly diffracting, radiation sensitive nano-samples (pharmaceuticals, protein nano-crystals,
zeolites and other nano-particles), which currently can only be studied in bulk. We will test to what extent
the detector can be used for imaging of radiation sensitive samples using geometric superresolution. Our
project will result in a scientific instrument that can be developed by Dectris into a commercial product.


Keywords Nano-crystallography, Hybrid pixel detector, Electron diffraction
Financed by Other sources
   

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