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GABAA receptor modulators inspired by natural products
Project funded by own resources
Project title GABAA receptor modulators inspired by natural products
Principal Investigator(s) Hamburger, Matthias
Project Members Faleschini, Maria Teresa
Organisation / Research unit Faculty of Science,
Departement Pharmazeutische Wissenschaften / Pharmazeutische Biologie (Hamburger)
Project start 01.03.2015
Probable end 30.04.2020
Status Completed
Abstract

A FLIPR-based assay for screening of the in-house extract library for allosteric GABAA receptor modulators has been established. As a follow-up, the most promising extracts are currently being followed up via HPLC-based activity profiling, to identify natural products with new scaffolds for the target. Structures are elucidated by NMR, HR-MS, ECD and VCD.

Keywords GABAA receptor modulators, allosteric, natural products, medicinal chemistry, blood-brain-barrier, metabolism
Financed by University funds

Cooperations ()

  ID Kreditinhaber Kooperationspartner Institution Laufzeit - von Laufzeit - bis
3394885  Hamburger, Matthias  Mihovilovic, Marko, Professor  Technical University of Vienna  01.03.2015  31.12.2018 
3394886  Hamburger, Matthias  Hering, Steffen, Professor  University of Vienna, Pharmacology and Toxicology  01.03.2015  31.12.2018 
   

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21/06/2024