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GABAA receptor modulators inspired by natural products
| Project funded by own resources |
| Project title |
GABAA receptor modulators inspired by natural products |
| Principal Investigator(s) |
Hamburger, Matthias
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| Project Members |
Faleschini, Maria Teresa
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| Organisation / Research unit |
Faculty of Science,
Departement Pharmazeutische Wissenschaften / Pharmazeutische Biologie (Hamburger) |
| Project start |
01.03.2015 |
| Probable end |
30.04.2020 |
| Status |
Completed |
| Abstract |
A FLIPR-based assay for screening of the in-house extract library for allosteric GABAA receptor modulators has been established. As a follow-up, the most promising extracts are currently being followed up via HPLC-based activity profiling, to identify natural products with new scaffolds for the target. Structures are elucidated by NMR, HR-MS, ECD and VCD. |
| Keywords |
GABAA receptor modulators, allosteric, natural products, medicinal chemistry, blood-brain-barrier, metabolism |
| Financed by |
University funds
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Cooperations () |
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ID |
Kreditinhaber |
Kooperationspartner |
Institution |
Laufzeit - von |
Laufzeit - bis |
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3394885 |
Hamburger, Matthias |
Mihovilovic, Marko, Professor |
Technical University of Vienna |
01.03.2015 |
31.12.2018 |
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3394886 |
Hamburger, Matthias |
Hering, Steffen, Professor |
University of Vienna, Pharmacology and Toxicology |
01.03.2015 |
31.12.2018 |
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24/04/2024
Research Database / FORSCHUNGSDATENBANK
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