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Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3394461
Author(s) Singh, Sandeep K; Stogsdill, Jeff A; Pulimood, Nisha S; Dingsdale, Hayley; Kim, Yong Ho; Pilaz, Louis-Jan; Kim, Il Hwan; Manhaes, Alex C; Rodrigues, Wandilson S; Pamukcu, Arin; Enustun, Eray; Ertuz, Zeynep; Scheiffele, Peter; Soderling, Scott H; Silver, Debra L; Ji, Ru-Rong; Medina, Alexandre E; Eroglu, Cagla
Author(s) at UniBasel Scheiffele, Peter
Year 2016
Title Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin
Journal Cell
Volume 164
Number 1-2
Pages / Article-Number 183-96
Abstract

Proper establishment of synapses is critical for constructing functional circuits. Interactions between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of synaptic adhesions. An isoform code determines the direct interactions of neurexins and neuroligins across the synapse. However, whether extracellular linker proteins can expand such a code is unknown. Using a combination of in vitro and in vivo approaches, we found that hevin, an astrocyte-secreted synaptogenic protein, assembles glutamatergic synapses by bridging neurexin-1alpha and neuroligin-1B, two isoforms that do not interact with each other. Bridging of neurexin-1alpha and neuroligin-1B via hevin is critical for the formation and plasticity of thalamocortical connections in the developing visual cortex. These results show that astrocytes promote the formation of synapses by modulating neurexin/neuroligin adhesions through hevin secretion. Our findings also provide an important mechanistic insight into how mutations in these genes may lead to circuit dysfunction in diseases such as autism.

Publisher Cell Press
ISSN/ISBN 0092-8674
edoc-URL http://edoc.unibas.ch/41404/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.cell.2015.11.034
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26771491
ISI-Number WOS:000368339300019
Document type (ISI) Journal Article
 
   

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