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Issues around the prescription of half tablets in northern Switzerland: the irrational case of quetiapine
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3389214
Author(s) Allemann, Samuel S.; Bornand, Delia; Hug, Balthasar; Hersberger, Kurt E.; Arnet, Isabelle
Author(s) at UniBasel Arnet, Isabelle
Hersberger, Kurt
Year 2015
Title Issues around the prescription of half tablets in northern Switzerland: the irrational case of quetiapine
Journal BioMed Research International
Volume 2015
Pages / Article-Number 602021
Keywords tablet splitting, quetiapine, Switzerland
Abstract Background. Prescription of fragmented tablets is useful for individualisation of dose but includes several drawbacks. Although without score lines, the antipsychotic drug quetiapine was in 2011 the most often prescribed 1/2 tablet in discharge prescriptions at the University Hospital in Basel (USB, 671 beds). We aimed at analysing the prescription patterns of split tablets in general and of quetiapine in particular in Switzerland. Methods. All orders of community pharmacies for unit-of-use soft pouch blisters placed at Medifilm AG, the leader company in Switzerland for repackaging into pouch blisters, were analysed. Results. Out of 4,784,999 tablets that were repacked in 2012 in unit-of-use pouch blisters, 8.5% were fragmented, mostly in half (87.6%), and were predominantly psycholeptics (pipamperone 15.8%). Prescription of half quetiapine appears to be a Basel specificity (highest rates of fragments and half quetiapine). Conclusions. Prescription of fragmented tablet is frequent. It represents a safety issue for the patient, and a pharmaceutical care issue for the pharmacist. In ambulatory care, the patient's cognitive and physical capacities must be clarified, suitability of the splitting of the tablet must be checked, appropriate aids must be offered, like a pill-splitting device in order to improve accuracy, and safe use of the drug must be ensured.
Publisher Hindawi
ISSN/ISBN 1110-7243 ; 1110-7251
edoc-URL http://edoc.unibas.ch/40992/
Full Text on edoc Available
Digital Object Identifier DOI 10.1155/2015/602021
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26539514
ISI-Number WOS:000363594400001
Document type (ISI) Journal Article
 
   

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