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Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3351739
Author(s) Gill, Mark E; Erkek, Serap; Peters, Antoine H F M
Author(s) at UniBasel Peters, Antoine
Year 2012
Title Parental epigenetic control of embryogenesis: a balance between inheritance and reprogramming?
Journal Current opinion in cell biology
Volume 24
Number 3
Pages / Article-Number 387-96
Abstract At fertilization, fusion of two differentiated gametes forms the zygote that is capable of forming all of the varied cell lineages of an organism. It is widely thought that the acquisition of totipotency involves extensive epigenetic reprogramming of the germline state into an embryonic state. However, recent data argue that this reprogramming is incomplete and that substantial epigenetic information passes from one generation to the next. In this review we summarize the changes in chromatin states that take place during mammalian gametogenesis and examine the evidence that early mammalian embryogenesis may be affected by inheritance of epigenetic information from the parental generation.
Publisher Elsevier
ISSN/ISBN 0955-0674
edoc-URL http://edoc.unibas.ch/40457/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.ceb.2012.03.002
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/22445736
ISI-Number WOS:000305860300012
Document type (ISI) Journal Article, Review
 
   

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