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Reconstituted Artificial Coronas: engineering nano-particles by in-silico protein mutagenesis
Third-party funded project |
Project title |
Reconstituted Artificial Coronas: engineering nano-particles by in-silico protein mutagenesis |
Principal Investigator(s) |
Schwede, Torsten
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Co-Investigator(s) |
Creus, Marc Haas, Jürgen
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Project Members |
Kedzierski, Thomas Rogaciano Ramalho, Ruben David
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Organisation / Research unit |
Departement Biozentrum / Bioinformatics (Schwede) |
Project Website |
http://www.ccmx.ch/home/ |
Project start |
01.10.2015 |
Probable end |
30.09.2018 |
Status |
Completed |
Abstract |
Nanoparticles (NP) are novel materials being used increasingly in a range of fields, including in medicine. When NP enter the blood stream, they often interact with proteins to form a "corona", which may change the properties and function of the nanoparticle; it is also thought that formation of the corona is related to toxic effects of nanoparticles. However, how proteins bind to NP and how exactly this protein-inorganic interaction occurs remains largely unknown; consequently, any prediction of corona formation and of potential toxicity of NP remains difficult.
In this project, we aim to study the interaction at the biological-inorganic interface, in specific model proteins binding to silica and gold NP of defined size and surface chemistry. Using a reiterative approach combining experiment and computation, hypotheses generated compitationally will be tested experimentally using recombinant protein mutants designed to probe potential interaction sites. |
Keywords |
Nanoparticles, biological-inorganic interface |
Financed by |
Public Administration
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Cooperations () |
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ID |
Kreditinhaber |
Kooperationspartner |
Institution |
Laufzeit - von |
Laufzeit - bis |
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3721759 |
Schwede, Torsten |
Wick, Peter |
EMPA Swiss Federal Laboratories for Materials Science and Technology |
01.10.2015 |
31.12.2018 |
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29/03/2024
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