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Reconstituted Artificial Coronas: engineering nano-particles by in-silico protein mutagenesis
Third-party funded project
Project title Reconstituted Artificial Coronas: engineering nano-particles by in-silico protein mutagenesis
Principal Investigator(s) Schwede, Torsten
Co-Investigator(s) Creus, Marc
Haas, Jürgen
Project Members Kedzierski, Thomas
Rogaciano Ramalho, Ruben David
Organisation / Research unit Departement Biozentrum / Bioinformatics (Schwede)
Project Website http://www.ccmx.ch/home/
Project start 01.10.2015
Probable end 30.09.2018
Status Completed
Abstract

Nanoparticles (NP) are novel materials being used increasingly in a range of fields, including in medicine. When NP enter the blood stream, they often interact with proteins to form a "corona", which may change the properties and function of the nanoparticle; it is also thought that formation of the corona is related to toxic effects of nanoparticles. However, how proteins bind to NP and how exactly this protein-inorganic interaction occurs remains largely unknown; consequently, any prediction of corona formation and of potential toxicity of NP remains difficult.

In this project, we aim to study the interaction at the biological-inorganic interface, in specific model proteins binding to silica and gold NP of defined size and surface chemistry. Using a reiterative approach combining experiment and computation, hypotheses generated compitationally will be tested experimentally using recombinant protein mutants designed to probe potential interaction sites.

Keywords Nanoparticles, biological-inorganic interface
Financed by Public Administration

Cooperations ()

  ID Kreditinhaber Kooperationspartner Institution Laufzeit - von Laufzeit - bis
3721759  Schwede, Torsten  Wick, Peter  EMPA Swiss Federal Laboratories for Materials Science and Technology  01.10.2015  31.12.2018 
   

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29/03/2024