Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 3197884
Author(s) Kaiser, Marcel; Mäser, Pascal; Tadoori, Leela Pavan; Ioset, Jean-Robert; Brun, Reto
Author(s) at UniBasel Kaiser, Marcel
Mäser, Pascal
Brun, Reto
Year 2015
Title Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning
Journal PLoS ONE
Volume 10
Number 8
Pages / Article-Number e0135556
Mesh terms Animals; Antiprotozoal Agents, therapeutic use; Cells, Cultured; Chagas Disease, drug therapy; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning, methods; Humans; Leishmania donovani, drug effects; Leishmaniasis, drug therapy; Macrophages, Peritoneal, parasitology; Malaria, drug therapy; Mice; Neglected Diseases, drug therapy; Plasmodium falciparum, drug effects; Trypanosoma brucei rhodesiense, drug effects; Trypanosoma cruzi, drug effects; Trypanosomiasis, African, drug therapy
Abstract Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria. Since drug development is lengthy and expensive, a drug repurposing strategy offers an attractive fast-track approach to speed up the process. A set of 100 registered drugs with drug repositioning potential for neglected diseases was assembled and tested in vitro against four protozoan parasites associated with the aforementioned diseases. Several drugs and drug classes showed in vitro activity in those screening assays. The results are critically reviewed and discussed in the perspective of a follow-up drug repositioning strategy where R&D has to be addressed with limited resources.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A6420002
Full Text on edoc Available
Digital Object Identifier DOI 10.1371/journal.pone.0135556
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/26270335
ISI-Number WOS:000359492800088
Document type (ISI) Journal Article
 
   

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